Effect of remote ischemic preconditioning on liver function in patients subjected to Coronary Artery Bypass Graft Surgery .

Effect of Remote Ischemic Preconditioning on Liver Function following Coronary Artery Bypass Graft Surgery: A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202107885974137

Enrollment

114

Registered

2021-07-05

Start date

2021-07-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

placebo

RIPC

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: adult patients of either sex, age >18 years old who will be scheduled for elective or urgent CABG surgery .

Exclusion criteria

Exclusion criteria: patient’s refusal, preoperative right sided heart failure, significant liver diseases, uncontrolled diabetes and/ or hypertention, preoperative renal diseases (serum creatinine ? 1.5 mg/dl), redo surgeries, and patients with significant acute or chronic upper limb ischemia

Design outcomes

Primary

Measure	Time frame
serum alanine transaminase (ALT) ..	—

Secondary

Measure	Time frame
serum levels of AST, GGt, total and direct bilirubin, albumin and prothrombine concentration, aortic cross clamp time, bypass time, UOP, fluid balance at the end of CPB and at 24 postoperative hour, bleeding, transfusion( RBCs, FFP, platelets ),incidence of intraoperative hypotension, need for DC shocks, pacing, number of grafts, the amount of consumed inotropes and ,vasoactive drugs (vasopressors and dilators), Serum MDA, IL1, TNFa and IL10 will be measured at the following times; before RIPC, after RIPC, at 6,12,24,48, and 72 hours after the end of ischemic cardioplegic arrest and duration of mechanical ventilation and length of ICU stay.	—

Measure

Time frame

serum levels of AST, GGt, total and direct bilirubin, albumin and prothrombine concentration, aortic cross clamp time, bypass time, UOP, fluid balance at the end of CPB and at 24 postoperative hour, bleeding, transfusion( RBCs, FFP, platelets ),incidence of intraoperative hypotension, need for DC shocks, pacing, number of grafts, the amount of consumed inotropes and ,vasoactive drugs (vasopressors and dilators), Serum MDA, IL1, TNFa and IL10 will be measured at the following times; before RIPC, after RIPC, at 6,12,24,48, and 72 hours after the end of ischemic cardioplegic arrest and duration of mechanical ventilation and length of ICU stay.

—

Countries

Egypt

Contacts

Public ContactMahmoud Abdelfattah

assistant lecturer of anesthesia and surgical intensive care

mahmoudabdelfattah945@gmail.com00201006192325

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026