Pregnancy and Childbirth
Conditions
Interventions
Control Group
Sponsors
Stellenbosch University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: All these criteria must be met to be eligible for inclusion: A) At high risk of developing preeclampsia: Pregnant women who have chronic hypertension AND/OR have had a previous pregnancy complicated by preterm preeclampsia (before 34 weeks gestation) AND/OR had preeclampsia complicating 2 or more previous pregnancies B) Gestational age between 12w 0d and 26w 0d C) Viable singleton pregnancy D) Be able to understand the information provided, with the use of an interpreter if needed, and be able to give informed consent E) Be willing to take the trial medication daily until delivery
Exclusion criteria
Exclusion criteria: Any of the following will be considered an exclusion criterion: A) Under 18 years of age B) Known fetal anomaly C) Unable or not willing to give consent D) Diabetes E) Contraindication to the use of metformin F) Currently using metformin G) Previously enrolled in this trial. Participants will only be able to enrol for this trial once and not again in the next pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis of preeclampsia or super-imposed preeclampsia | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnosis of preeclampsia or super-imposed preeclampsia <37 weeks;Diagnosis of preeclampsia or super-imposed preeclampsia <34 weeks;Diagnosis of any hypertensive disorder of pregnancy after enrollment | — |
Countries
South Africa
Contacts
Public ContactCatherine Cluver
Associate Professor
Outcome results
None listed