Evaluation of population diversity of Plasmodium falciparum isolates from children with uncomplicated infection during the adoption of artemisinin-based combination therapy in Nigeria

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202106708800075

Enrollment

Registered

2021-06-23

Start date

2021-06-21

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Interventions

Dihydroartemisinin piperaquine

Artemether Lumefantrine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age History of fever or fever (temp > 37.5oC) Mono P. falciparum infection with asexual parasitemia of =2000 mL-1 Written informed consent, including readiness to comply with follow-up visits by the child’s parent or guardian.

Exclusion criteria

Exclusion criteria: Signs of severe malaria severe malnutrition History of allergy to study drug

Design outcomes

Primary

Measure	Time frame
Responsiveness to drug treatment would be measured through Asexual parasite positivity, Parasite clearance time, Adequate clinical and parasitological response, terminal elimination halftime of asexual parasitaemia, area under curve of asexual parasitaemia, fever clearance time and anaemia recovery time.	—

Secondary

Measure	Time frame
Semi-nested PCR amplification of 12 P. falciparum microsatellite loci will be used to determine the population diversity of isolates from children with uncomplicated infection.	—

Countries

Nigeria

Contacts

Public ContactKazeem Akano

Lecturer

akanok@run.edu.ng+2348038644138

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026