Nervous System Diseases
Conditions
Interventions
rTMS sessions
Sham rTMS
Sponsors
Neurology department Ain Shams University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria: • Age: 45 years or older. • Sex: males and females. • MMSE more than or equal to 24 • MRI brain Suggestive of Small vessel disease in the form of Deep white matter ischemia, Cerebral Microbleeds and Enlarged Virchow spaces. • Patients presenting with Cognitive, Urinary and Gait abnomalities rather than Acute stroke presentation. • No significant Carotid artery stenosis ( Diffuse cartoid artery atherosclerosis is accepted )
Exclusion criteria
Exclusion criteria: • Diagnosis of acute ischemic stroke or history of manifested ischemic stroke. • Other determined etiology and undetermined etiology stroke subtypes according to TOAST classification. • Conditions that contraindicate rTMS: • Skull defects or fractures • Epilepsy • Skin scalp hematoma • Scalp infection • DBS ( Deep brain stimulation) • Pacemaker • Conditions that Raise IL-1 levels: • Presence of cancer. • Receiving thrombolytic therapy. • Patients with hematological diseases. • Patients with severe renal or liver failure. • Patients who are under treatment with anti-inflammatory drugs, Immunosuppressive or immunomodulatory drugs for any medical disease in the last six month. • Patients with active fever. • Patients with a rheumatologic disease. • Multiple Sclerosis. • Brain tumors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •Clinical Tools for Cognition: Frontal Assessment Battery, Adam Brook test •Clinical Tools for Gait: Berg balance test- 10 meter walk- Timed up and Go test ( TUG) – Minibest scale •Clinical Tools for Urinary symptoms: The International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1 B serum levels | — |
Countries
Egypt
Contacts
Public ContactEman Hamid
Lecturer of Neurology Ain Shams University
Outcome results
None listed