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Effect of intraoperative restrictive fluid therapy versus goal directed fluid therapy on postoperative pulmonary complications in sitting or prone neurosurgical patients

Effect of intraoperative restrictive fluid therapy versus goal directed fluid therapy on postoperative pulmonary complications in sitting or prone neurosurgical patients

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
PACTR
Registry ID
PACTR202103623159030
Enrollment
70
Registered
2021-03-29
Start date
2021-04-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

intraoperative restrictive fluid therapy
Cardiometry guided goal directed fluid therapy

Sponsors

Anesthesia department faculty of medicine tanta university
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: ? Participants: adult patients aged 21 – 60 years. ? Inclusion criteria • Patients scheduled for neurosurgery in abnormal position (sitting or prone) with expected marked fluid shift. • Age from 21 to 60 years old. • Patients with GCS 15 (fully conscious). • ASA physical status II or III. • Competence to consent.

Exclusion criteria

Exclusion criteria: • Patients refuse to participate in our study. • Patients with BMI more than 35 or less than 25. • Patients with cardiac arrhythmia (limitation to use stroke volume variation as an indicator of fluid responsiveness). • Significant renal dysfunction (serum creatinine > 1.5 mg/dl). • Severe heart failure (New York Heart Association classification 3 or 4). • Severe uncontrolled pulmonary disease. • Non-extubated patients.

Design outcomes

Primary

MeasureTime frame
Lung ultrasound score

Secondary

MeasureTime frame
total intraoperative fluid requirements, number of fluid boluses, number of patients requiring vasopressors, and urine output, postoperative pulmonary complications, postoperative morbidity (the proportion of patients who developed one or more complications), and ICU length of stay.

Countries

Egypt

Contacts

Public ContactKamal Heikal

Professor of anesthesiology and surgical ICU and pain medicine faculty of medicine tanta university

kamal.hekal@med.tanta.edu.eg01223446472

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026