Malaria
Conditions
Interventions
Parenteral dual artemisinin based antimalarial artesunate and quinine
Monotherapy with either quinine alone or artesunate alone
Sponsors
Alao Michael and Co Authors
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Children between the ages of 6 months to 17 years as at the last birthday 2.Children with unarousable coma lasting more than 30 minutes in the presence of demonstratable peripheral asexual P. falciparum parasitemia. 3.Children who develop deterioration in their level of consciousness after admission and demonstrate asexual Plasmodium falciparum in the peripheral blood.
Exclusion criteria
Exclusion criteria: 1.Children with positive biochemical and/or microbiological CSF result consistent with a diagnosis of meningitis 2.Children who have intracranial infections or intracranial space-occupying lesions 3.Children with previous neurological deficit either focal or global
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the effectiveness of dual parenteral antimalaria in the treatment of cerebral malaria compared to the standard of care in terms of survival and full recovery in tertiary hospitals in Nigeria. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes include the parasite clearance rate, fever defervescence, time to recovery of consciousness, and the side effect profile of interventions (treatment and control arms). | — |
Countries
Nigeria
Contacts
Public ContactAbayomi Oyenuga
Clinician Biostatistician
Outcome results
None listed