Haematological Disorders Pregnancy and Childbirth postpartum hemorrhage Anaesthesia
Conditions
Interventions
placebo group
study group
Sponsors
Faculty of medicine Ain Shams University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Singleton pregnancy, P1-CS (previous one section after failed consent for trial of labor after CS), Term = 37 weeks of gestation , Elective cesarean section, spinal anesthesia and written Informed consent.
Exclusion criteria
Exclusion criteria: Failed spinal anesthesia (more than 2 attempts), Multiple pregnancy, Grand multipara, Placenta previa, Abruptio placentae, Polyhydraminos, Fever, Rupture of membranes, Patients on anticoagulants or antiplatelets, History of eclampsia or pre-eclampsia in current pregnancy, History of cardiovascular complications as Coronary artery disease or myocardial infarction, Repaired or unrepaired congenital heart disease, unstable arrhythmia or Congestive heart failure, or the patient had a contraindication to TXA administration as history of venous thromboembolism, active thromboembolic disease, high risk of thrombosis (e.g. factor V Leiden or protein C deficiency), allergy to TXA, Pre-existing hematuria or history of renal insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of our study is the amount of blood loss during and after CS; which was estimated by calculating the blood loss using standard equations by using preoperative and 24 hours postoperative hematocrit value as follows: 1.Estimate blood volume for women 65 ml/kg. 2.Estimate the red blood cell volume (RBCV) at the preoperative hematocrit (RBCVpreop). 3.Estimate RBCV at the postoperative hematocrit (RBCVpostop), assuming normal blood volume is maintained. 4.Calculate the RBCV lost: RBCVlost = RBCVpreop – RBCVpostop 5.Blood loss = RBCV lost × 3. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures were Vital signs (pulse, blood pressure, respiratory rate) during first 6 hours postoperatively and 24 hours post-operative hemoglobin and hematocrit values. Any complication that could be reported such as the need for blood transfusion or the need for any surgical measures to stop bleeding was recorded. | — |
Countries
Egypt
Contacts
Public ContactWalid Basuony
professor
Outcome results
None listed