Comparison between metoprolol and pregabalin as premedication in spine surgery

Comparison between Metoprolol and Pregabalin as a Premedication for Controlled Hypotension in Spine Surgery

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

PACTR

Registry ID

PACTR202102522324854

Enrollment

Registered

2021-02-17

Start date

2019-08-08

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Metoprolol group

Pregabalin group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ASA physical status I, aged from 18 to 50 years old scheduled for elective spine fixation surgeries will included In this study

Exclusion criteria

Exclusion criteria: Any patient who has any of following will be excluded Hypertension, Diabetes mellitus, hepatic or renal disease, pregnancy, coagulation disorders, Anemia ( HB<10) , Ischaemia heart disease, drug or alcohol abuse, allergy to any of metoprolol or pregabalin, history of beta blockers, calcium channel blocker, tricyclic antidepressants, anticoagulant or clonidine intake

Design outcomes

Primary

Measure	Time frame
The primary aim of this study is to compare between metoprolol and pregabalin as premedication to induce controlled hypotensive anesthesia primarily control heart rate in spine surgery	—

Secondary

Measure	Time frame
The secondary aims is to assess field visualization and measure the amount of blood loss in patients of both groups, surgeons satisfaction and also to assess if there are any associated undesirable side effects of metoprolol or pregabalin wil appear	—

Countries

Egypt

Contacts

Public ContactOsama El sharkawy

Professor of anaesthesia and intensive care faculty of medicine menoufia university

docmaive92@gmail.com0201223824088

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026