Oral Health
Conditions
Interventions
Placebo
Single dose of antibiotic
postoperative antibiotic
Sponsors
Research Laboratory LR 12SP10 Functional and Aesthetic Rehabilitation of Maxillary
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Male or female patients 18 years or older Patients with known history of insulin-dependent diabetes or noninsulin-dependent diabetes mellitus with glycosylated hemoglobin levels between 8% and 11% the previous two to three months. Extraction requiring minimal instrumentations.
Exclusion criteria
Exclusion criteria: Surgical extraction procedure Immuno compromised patients or patient having diseases or conditions associated with impaired wound or osseous healing like: HIV,AIDS,hematologicalneoplasia, following transplant surgery,patient undergoing chemotherapy,patient under or with antecedents of antiresorptive drugs administration (bisphosphonate, denosumab),patient undergoing or with history of radiation in the maxillafacial region,patient under immunosupressive drugs: corticosteroids, thalidomide Patients undergoing extractions of endodontically treated teeth Patient currently taking antibiotics at the time of extraction or have had antibiotics less than 3days prior to extraction Patient with habits wich are known to be determinal to oral wound healing such as smoking, alcohool… Co-existing of local or systemic infection Pregnant and lacting patients Recent use of any anti-inflammatory drugs (used within one month previous) Allergy to drugs used in the study Patients taking antibiotics within 1 week after extraction for other infectious diseases. Having a dental emergency Having acute dental or periodontal infections requiring antibiotic prescription
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of postoperative complication including: Dry socket: persistent pain and exposure of the alveolar bone. Suppurated alveolitis: which identified by provoked pain and alveolus filled; the clot becomes infected, covered by a grayish green membrane and it may consists of dental fragments or osseous sequestrum. Abscess: Localized bacterial infection, localized pain and swelling, it may present clinically as a fluctuant buccal or palatal swelling, with or without a draining fistula. Cellulitis: may follow tooth extraction if the infection spreads into the surrounding tissues. Diffuse, tense, painful swelling of the affected tissues occurs. Regional lymphadenopathy is common, and fever may be present. | — |
Secondary
| Measure | Time frame |
|---|---|
| Delayed wound healing: According to the literature, the dental alveolus is filled with blood clot and fibrin at 3 days after dental extraction; on postoperative day 7, the alveolus is filled with granulation tissue; on postoperative day 21, wound epithelialization is complete; and on postoperative day 60, alveolar bone formation can be observed on a dental radiographic image. Delayed wound healing was defined as a delay in any of the aforementioned events | — |
Countries
Tunisia
Contacts
Public ContactBoughzala Abdellatif
Oral Surgery Unit Dental Medicine Department in University Hospital Farhat Hached
Outcome results
None listed