Primary postpartum Haemorrhage
Conditions
Interventions
Tranexamic acid administered to the consenting patients who meet the inclusion criteria
Sterile water
Sponsors
Dr Igboke Francis N
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Spontaneous labour in booked patients 2. Planned vaginal delivery 3. Term pregnancy 4. Singleton pregnancy and cephalic presentation 5. Parturient who has no contraindication to the use of tranexamic acid 6. Informed consent form signed
Exclusion criteria
Exclusion criteria: 1. Women with prior history of thromboembolism/autoimmune/ sickle cell disease 2. Women with bleeding disorders 3. Patients with renal disease, liver pathology, known cardiovascular disease 4. Multiple pregnancy/intra-utero fetal death/previous uterine surgeries 5. Patients with chronic hypertension 6. Patients with preeclampsia/eclampsia/HELLP syndrome 7. Women with antepartum haemorrhage/ruptured uterus 8. Patients with varicose veins at increased risk of deep vein thrombosis 9. History of epilepsy/seizure 10. Episiotomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Estimated blood loss following vaginal delivery (total blood loss following vaginal delivery= estimated blood from cylinder+ difference in the weight of pad) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Primary PPH following vaginal delivery defined as blood loss > 500ml 2. The need for additional uterotonics to control bleeding 3. The need for blood transfusion (volume and amount) after vaginal delivery 4. Mild maternal side effects (nausea, vomiting, headache, skin rash) 5. Major maternal side effects (thromboembolism, maternal death) | — |
Countries
Nigeria
Contacts
Public ContactOsaheni Lucky Lawani
Consultant
Outcome results
None listed