Prevention of Post Operative Sore Throat: Comparing Intravenous Lidocaine, Intra-Cuff Alkalinized Lidocaine and Placebo. A Randomized Controlled Trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202009875831645

Enrollment

Registered

2020-09-17

Start date

2019-05-26

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Group T

Group S

Group L

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Age above 18 years old. - Patients receiving elective visceral, urologic, orthopedic or plastic surgeries. - American Society Of Anesthesiologists (ASA) score of 1, 2 or 3. - Easy predicted intubation. - Intubation time estimated equal or less than 240 minutes.

Exclusion criteria

Exclusion criteria: - Patient’s refusal. - Rapid sequence induction (RSI) - Predicted airway management difficulty. - Patient’s history of recent airway inflammation, injury or tumor. - Contraindication for the use of drugs necessary for the protocol. - ASA score of more than 3. - Intubation time estimated more than 240 minutes. - Use of supra-glottic tools for airway management. - Laparoscopic surgery. - Intubation time more than 240 minutes. - Airway management difficulty. - Traumatic airway management. - Accidental extubation. - Per-operative or recent re-intubation. - Broncho / laryngospasm. - Per-operative anaphylactic or allergic reaction. - Use of corticosteroids. - Anesthetic-protocol modifications.

Design outcomes

Primary

Measure	Time frame
We evaluated the incidence of sore throat at the sixth then twenty-fourth post-operative hour as a primary outcome. Patients had to answer to a “YES” or “NO” question: “do you feel having a sore throat?”. Throat pain was quantified using the Visual Analogic Scale (VAS): VAS had to be above 10 out of 100 to confirm a “Yes” answer.	—

Secondary

Measure	Time frame
Hemodynamic variations during orotracheal intubation and extubation:;The incidence of cough at orotracheal intubation and emergence of anesthesia.;The incidence of cough at the 6th and 24th post-operative hours;The incidence of dysphonia at the 6th and 24th post-operative hours;The incidence of dysphagia at the 6th and 24th post-operative hours;The incidence of nausea and vomiting at the 6th and 24th post-operative hours	—

Measure

Time frame

Hemodynamic variations during orotracheal intubation and extubation:;The incidence of cough at orotracheal intubation and emergence of anesthesia.;The incidence of cough at the 6th and 24th post-operative hours;The incidence of dysphonia at the 6th and 24th post-operative hours;The incidence of dysphagia at the 6th and 24th post-operative hours;The incidence of nausea and vomiting at the 6th and 24th post-operative hours

—

Countries

Tunisia

Contacts

Public ContactSalma Ketata

Assistante Hospitalo Universitaire

slayma@hotmail.com0021696107594

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026