Nutritional, Metabolic, Endocrine
Conditions
Interventions
Group C
Group B
Group A
Group D
Sponsors
National Institute of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (i) delivery vaginally or by cesarean section, (ii) an infant age of 6 months (±3 weeks), (iii) mother =15 years of age, (iv) infant still breastfeeding, and (v) anticipated residence in the area for the study duration.
Exclusion criteria
Exclusion criteria: (i) inability to provide informed consent, (ii) hemoglobin < 70 g/L, (iii) Z scores for weight-for-age (WAZ) or weight-for-height (WHZ) <3, (iv) any maternal or infant chronic illness, (v) administration of any vitamin or mineral supplements for the past 2 months, and (vi) any history of antibiotic treatment in the past seven days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure will be the ratio of the abundances of potentially harmful (enteropathogenic and/or enterotoxigenic E. coli, C. difficile, members of the C. perfringens group, B. cereus, S. aureus, sum of Shigella spp., and Salmonella) to beneficial (bifidobacteria and the group of Lactobacillus/Leuconostoc/Pediococcus spp.) bacterial genera at 1 month. | — |
Secondary
| Measure | Time frame |
|---|---|
| The ratio of the abundances of potentially harmful to beneficial bacterial genera ratios and comparisons of microbiota composition at all time points, including assessment of effects of helminth infections. ;The prevalence of diarrhea, malaria, anemia, iron deficiency, iron deficiency anemia, inflammation, respiratory tract infections, and other illnesses. | — |
Countries
Kenya
Contacts
Public ContactNicole Stoffel
Post Doc at ETH Zurich
Outcome results
None listed