Fertility-female
Conditions
Interventions
Autologous adipose derived stem cell insertion into ovary
Placebo injection into ovary
Sponsors
Oxford road Day clinic
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: - Infertile women with either premature ovarian failure diagnosed clinically and biochemically - Infertile women with very low ovarian reserves diagnosed both biochemically with low AMH and radiologically with low AFC - Eligible women must consent to partake in the study
Exclusion criteria
Exclusion criteria: - A history of current or previous malignancy - Any other co-existing cause of infertility in the couple (male or female factors) - The inability to visualize the ovaries on transvaginal ultrasound - Age >42 years - Smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)hormonal biomarkers indicating recovery of ovarian function; (a decline in FSH and a rise in AMH) 2)resumption of menstruation in amenorrheic women 3)response to ovarian stimulation, oocyte quantity obtained, embryo grading, euploidy rates and pregnancy outcome | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) to determine the optimal concentration of stem cells to be used 2) to determine the effects of ovarian perfusion on stem cell grafting 3) to determine the ideal patient candidate who is likely to benefit from stem cell therapy. | — |
Countries
South Africa
Contacts
Public ContactJamila Kathoon Adam
Supervisor
Outcome results
None listed