AMETHIST (Adapted Micro planning: Eliminating Transmissible HIV In Sex Transactions) Trial

Differentiated Prevention and Care to Support the Virtual Elimination of risk of acquisition and or transmission of HIV Among Sex Workers in Southern Africa - AMETHIST (Adapted Micro planning: Eliminating Transmissible HIV In Sex Transactions)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202007818077777

Enrollment

4400

Registered

2020-07-02

Start date

2019-01-29

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS

Interventions

Microplanning HIV prevention and care differentiated community support model for FSW in Zimbabwe

Usual Care

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Any sex workers regardless of age, gender or place of residence can attend the programme at any AMETHIST trial site (intervnetion or control). Eligibility for the outcome survey in June 2021. • Female • Age 18 or older • Currently working as a sex worker (has exchanged sex for money in the past 30 days) • Living or working in the study site (for at least 1 month).

Exclusion criteria

Exclusion criteria: The following are in eligible for the outcome survey in June 2021. • Male or transgender • Under 18 • Already participated in the current round of the survey • Visiting the study site temporarily (for less than 1 month) • Not currently working as a sex worker (verification questions will be used to prevent fraudulent participation, such as about how sex work is organised in the area and the cost of different sex acts)

Design outcomes

Primary

Measure	Time frame
% of all FSW recruited to RDS survey who are HIV negative and who are not taking PrEP and report condomless sex in the past month (i.e. at risk of HIV acquisition) OR who are HIV positive and have Viral Load > 1,000copies/µl and report condomless sex in the past month (i.e. who are at risk of HIV transmission).	—

Secondary

Measure	Time frame
% of all FSW recruited to the RDS survey who are HIV negative and who are not taking PrEP (verified by drug levels - at risk of HIV acquisition ) OR who are HIV positive and have Viral Load > 1,000copies/µl (i.e. who are at risk of HIV transmission). ;% of all FSW recruited to the RDS survey who have had contact with the Sisters programme in the last year and who are HIV negative and who are not taking PrEP and report condomless sex in the past month. (i.e. at risk of HIV acquisition) OR who are HIV positive and have Viral Load > 1,000copies/µl and report having condomless sex in the past month (i.e. who are at risk of HIV transmission). ;% of FSW who enrolled in AMETHIST intervention compared with individually matched controls who are either HIV negative and who are not taking PrEP and report condomless sex in the past month (i.e. at risk of HIV acquisition) OR who are HIV positive and have Viral Load > 1,000copies/µl and report having condomless sex in the past month (i.e. who are at risk of HIV transmission). ;The proportion of those taking ART who have viral load >1000 and have drug resistance to their current regimen;Self-reported quality of life, psychological health and functioning;Perceived levels of peer support	—

Measure

Time frame

% of all FSW recruited to the RDS survey who are HIV negative and who are not taking PrEP (verified by drug levels - at risk of HIV acquisition ) OR who are HIV positive and have Viral Load > 1,000copies/µl (i.e. who are at risk of HIV transmission). ;% of all FSW recruited to the RDS survey who have had contact with the Sisters programme in the last year and who are HIV negative and who are not taking PrEP and report condomless sex in the past month. (i.e. at risk of HIV acquisition) OR who are HIV positive and have Viral Load > 1,000copies/µl and report having condomless sex in the past month (i.e. who are at risk of HIV transmission). ;% of FSW who enrolled in AMETHIST intervention compared with individually matched controls who are either HIV negative and who are not taking PrEP and report condomless sex in the past month (i.e. at risk of HIV acquisition) OR who are HIV positive and have Viral Load > 1,000copies/µl and report having condomless sex in the past month (i.e. who are at risk of HIV transmission). ;The proportion of those taking ART who have viral load >1000 and have drug resistance to their current regimen;Self-reported quality of life, psychological health and functioning;Perceived levels of peer support

—

Countries

Zimbabwe

Contacts

Public ContactFortunate Machingura

Research Director Key Populations

fmachingura@ceshhar.co.zw+263772971481

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026