Potential therapeutic effect induced by melatonin supplementation and combined physical activity on postural stability and biological responses in obese patients

Acute melatonin ingestion reduced muscle damage, inflammation and oxidative stress after an exhaustive exercise in obese patients.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202006677216503

Enrollment

Registered

2020-06-19

Start date

2018-03-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional, Metabolic, Endocrine

Interventions

melatonin session

Placebo session

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Age 20-50 years - BMI> 30 kg / m2 - Circumference of height> 94 cm (man) - Circumference of the waist> 80 cm (woman) - No use of medication - No regular exercise for at least 6 months

Exclusion criteria

Exclusion criteria: - Against indication to the effort - Antecedent injury - Cardiorespiratory disease - Diabetes type 2 - Smoker

Design outcomes

Primary

Measure	Time frame
- inflammation - oxidative stress - muscle damage - cardiovascular function - aerobic capacity - psychological state (anxiety, depression, fatigue) - complete blood count	—

Secondary

Measure	Time frame
- body mass index - temperature - Heart rate - Systolic and diastolic arterial pressure - lipid profile	—

Countries

Tunisia

Contacts

Public ContactMouna Turki

Research Laboratory molecular bases of human pathology LR19ES13 Faculty of medicine of Sfax Sfax University Tunisia

mouna.turki@gmail.com+21698338230

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026