COVID-19
Conditions
Interventions
Usual standard of care at the study hospital
aspirin
losartan
simvastatin
Aspirin and Losartan
Aspirin and Simvastatin
Losartan and Simvastatin
AspirinLosartanSimvastatin
Sponsors
London School of Hygiene and Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adults age 40 years and older with suspected or confirmed acute COVID-19 infection (We use the following WHO criteria for a suspected case: A. A patient with acute respiratory illness (fever and at least one sign or symptom of respiratory disease, e.g., cough, shortness of breath), AND a history of travel to or residence in a location reporting community transmission of COVID-19 disease during the 14 days prior to symptom onset; OR B. A patient with any acute respiratory illness AND having been in contact with a confirmed or probable COVID-19 case in the last 14 days prior to symptom onset; OR C. A patient with severe acute respiratory illness (fever and at least one sign/symptom of respiratory disease, e.g., cough, shortness of breath; AND requiring hospitalization) AND in the absence of an alternative diagnosis that fully explains the clinical presentation.) requiring hospitalisation
Exclusion criteria
Exclusion criteria: Women known to be pregnant Patients hospitalised without symptoms of acute COVID-19 infection should not be recruited even if they test positive for COVID-19 Patients already receiving mechanical ventilation via an endotracheal tube Patients already receiving any of the trial treatments Patients with a definite indication or contraindication for any of the trial treatments. Patients who are very severely frail (completely dependent and approaching end of life who typically they could not recover even from a mild illness) or terminally ill should not be recruited.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In-hopsital death. Cause of death will be described | — |
Secondary
| Measure | Time frame |
|---|---|
| myocardial infarction, cardiac failure, severe cardiac arrhythmia, myocarditis, respiratory failure including ARDS, viral pneumonitis, acute renal failure, sepsis, stroke, gastrointestinal bleeding, receipt of non-invasive or mechanical ventilation requiring endotracheal intubation, ability to self-care at hospital discharge and time to hospital discharge. | — |
Countries
Nigeria, Pakistan
Contacts
Public ContactDanielle Beaumont
Senior Trial Manager
Outcome results
None listed