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The effect of intra-dialytic combined strength-endurance training and melatonin supplementation on biochemical, immune and physiological responses (renal and cardiovascular function), physical capacity and quality of sleep in hemodialysis patients

The effect of intra-dialytic combined strength-endurance training and melatonin supplementation on biochemical, immune and physiological responses (renal and cardiovascular function), physical capacity and quality of sleep in hemodialysis patients

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
PACTR
Registry ID
PACTR202005770507528
Enrollment
45
Registered
2020-05-04
Start date
2020-06-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Disease

Interventions

Control Group
Training group

Sponsors

Research Laboratory molecular bases of human pathology LR19ES13 Faculty of medicine of Sfax
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: -Patients on stable dialysis treatment (> 3 months on hemodialysis with adequate dialysis efficiency) (4 h / day, 3 days / week). -Aged between 20 and 60. -Body mass index (BMI) (kg·m - 2) between 18.5 and 24.9

Exclusion criteria

Exclusion criteria: The development of a serious condition requiring hospitalization or preventing exercise. -Participation in a physical rehabilitation program during the past year. - Orthopedic problems - Presence of chronic respiratory and cardiac diseases. -Thrombosis -Ischemic heart disease - Uncontrolled hypertension - Severe dyspnea

Design outcomes

Primary

MeasureTime frame
The height and body mass, body mass index

Secondary

MeasureTime frame
- immune function and inflammation - oxidative stress - muscle damage - hemodynamic balance -vascular function -Postural stability - Isokinetic muscle strength - Aerobic capacity - Quality of life - Psychological state (anxiety and depression) - The quality of slee

Countries

Tunisia

Contacts

Public ContactMouna Turki

Research Laboratory molecular bases of human pathology LR19ES13 Faculty of medicine of Sfax Sfax University Tunisia

mouna.turki@gmail.com+21698338230

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026