Hemodynamic effects of simultaneous infusion of Milrinone and Terlipressin in pediatric patients with pulmonary hypertension undergoing on pump cardiac surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202005520371433

Enrollment

Registered

2020-05-08

Start date

2020-04-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System Surgery Paediatrics Cardiology Anaesthesia

Interventions

Placepo group

Terlipressin

norepinephrine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The study will be conducted on 75 patients of either sex with the following inclusion criteria 1. Age 1–4 years. 2. Elective corrective open heart surgery using cardiopulmonary bypass (CPB). 3. Congenital cardiac anomalies associated with pulmonary hypertension (PAH-CHD) with pulmonary artery pressure (PAP) more than 40 mmhg.

Exclusion criteria

Exclusion criteria: 1. Patients with previous open heart surgery. 2. Neurological, renal or hepatic disease. 3. Decompensated heart failure. 4. Eisenmenger syndrome or right to left shunts. 5. Presence of preoperative coagulation disorders. 6. Contraindication to use TEE. 7. Hypersensitivity of any of the studied drugs.

Design outcomes

Primary

Measure	Time frame
assess systolic pulmonary artery pressure in the intra-operative and 24 hours post-operative periods.	—

Secondary

Measure	Time frame
the patients' heart rate, blood pressure, TEE data, arterial blood gases tensions, time of extubation and ICU and hospital length of stays.	—

Countries

Egypt

Contacts

Public ContactNabil Abdelraouf

Professor of anesthesia and surgical Intensive care at faculty of medicine Mansoura universit

nabil_abdelraouf@yahoo.com+201001538648

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026