vitamin E in tournique induced ischemic reperfusion injury in knee arthroplasty

Anti-inflammatory effect of vitamin E on tourniquet induced ischemic reperfusion injury in total knee arthroplasty: A prospective randomized controlled trial.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202004905009395

Enrollment

Registered

2020-04-17

Start date

2020-04-07

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

vit E

placebo group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: adults both sex ASA I or II aging 18-65 years undergoing total knee arthroplasty surgery in mansoura university hospitals.

Exclusion criteria

Exclusion criteria: 1-Patient refusal 2-Major cardiopulmonary disorders 3-Hepatic or renal disorders 4-Patient with relative contraindication for tourniquet use (as peripheral vascular disease, sickle cell anemia, deep venous thrombosis, diabetic neuropathy and crushed injury). 5- Rheumatoid arthritis. 6- Chron¬ic administration of anti-inflammatory drugs.

Design outcomes

Primary

Measure	Time frame
interlukin 6.	—

Secondary

Measure	Time frame
tumor necrosis factor TNF, Malondialdehyde MDA;HR, MABP, Spo2, RR ;-PH, PCO2, PO2, K, serum lactate	—

Countries

Egypt

Contacts

Public Contactsamah elkenany

assistant proffesor of anaesthesia mansoua university

sk_20022000@yahoo.com00201002262557

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026