The effect of low dose ketamine infusion on perioperative opioid requirements in pediatric on pump cardiac surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202003519479017

Enrollment

Registered

2020-03-04

Start date

2020-02-29

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paediatrics Anaesthesia

Interventions

placebo control group

Ketamine Group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: This study will be conducted on 76 patients of either sex with their age ranging from 2 to 12 years submitted for on pump elective repair of congenital simple left to right intra cardiac shunt via median sternotomy.

Exclusion criteria

Exclusion criteria: Patients will be excluded from the current study in case of refusal of their guardians, redo cardiac surgery, hypersensitivity to ketamine, coagulation disorders, renal, hepatic or pulmonary disease, heart failure and moderate to severe pulmonary hypertension.

Design outcomes

Primary

Measure	Time frame
1- Total dose of postoperative morphine consumption during the postoperative 48 hours. 2- Post operative pain that will be assessed at 1h, 2h, 6h, 12h, 18 h, 24 h, 36 h,48 h after extubation, and will be managed according to objective pain discomfort score(OPDS) in children.	—

Secondary

Measure	Time frame
1-Heart rate [HR] and invasive mean arterial blood pressure [MAP] will be recorded; before induction of anesthesia (basal value), after induction of anesthesia, after skin incision, after sternotomy, 15 min after CPB and after the closure of sternum. 2- Total dose of intra operative fentanyl requirements(ug/kg). 3- Aortic cross clamping time (minutes). 4- Cardiopulmonary bypass time (minutes). 5-The number of patients who will be extubated in operating room (within 15 minutes of the end of surgery) were recorded. 6- Time to extubation (hours). 7- Post extubation PaO2, PaCO2 will be assessed each 3 hour for 24 hours. 8-Time of first rescue analgesia 9- Total dose of morphine consumption in the first 48 postoperative hours. 10- Intensive care unit (ICU) length of stay. 11- Postoperative complications (the need for re-intubation, nausea and vomiting, pruritus, respiratory depression and neurological deficits) will be reported.	—

Measure

Time frame

1-Heart rate [HR] and invasive mean arterial blood pressure [MAP] will be recorded; before induction of anesthesia (basal value), after induction of anesthesia, after skin incision, after sternotomy, 15 min after CPB and after the closure of sternum. 2- Total dose of intra operative fentanyl requirements(ug/kg). 3- Aortic cross clamping time (minutes). 4- Cardiopulmonary bypass time (minutes). 5-The number of patients who will be extubated in operating room (within 15 minutes of the end of surgery) were recorded. 6- Time to extubation (hours). 7- Post extubation PaO2, PaCO2 will be assessed each 3 hour for 24 hours. 8-Time of first rescue analgesia 9- Total dose of morphine consumption in the first 48 postoperative hours. 10- Intensive care unit (ICU) length of stay. 11- Postoperative complications (the need for re-intubation, nausea and vomiting, pruritus, respiratory depression and neurological deficits) will be reported.

—

Countries

Egypt

Contacts

Public ContactNabil Abd Elraouf

Professor of anesthesia and surgical Intensive care at faculty of medicine Mansoura university

nabil_abdelraouf@yahoo.com+201001538648

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026