Nutritional, Metabolic, Endocrine Kidney Disease
Conditions
Interventions
B glucan prebiotic fibre
Sponsors
No sponsors
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with CKD stage 4 (GFR 15-29 ml/min) and 5 (GFR<15 ml/min) pre-dialysis patients attending the Tygerberg Renal Outpatient Clinic. Patients have to be 18 years or older and able to give informed written consent.
Exclusion criteria
Exclusion criteria: Patients on antibiotics, prebiotics or probiotic supplements currently or in the past 4 weeks. Patients with inflammatory bowel disease, bowel malignancy, previous colorectal surgery (or any other serious bowel disorder) Pregnancy, diabetes mellitus, coeliac disease, human immunodeficiency virus (HIV) disease, malignant hypertension, crescentic glomerular nephritis Patients on immunosuppressant medications. CKD patients who are expected to start dialysis within the next 2 months will be excluded. The conditions mentioned above are excluded due to it influencing either the gut microbiome or renal outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study the effect of the prebiotic on the following outcomes, sociodemographic outcomes, anthropometric outcomes, kidney and other biochemical outcomes, gut microbiome composition outcomes, uremic toxin composition outcomes, dietary adherence outcomes | — |
Secondary
| Measure | Time frame |
|---|---|
| To describe the meal patterns, cooking patterns and barriers to healthy eating | — |
Countries
South Africa
Contacts
Public ContactZarina Ebrahim
Lecturer and PhD student
Outcome results
None listed