Early Prediction of Acute Kidney Injury post operative

Early Prediction of Acute Kidney Injury with Cell Cycle Arrest Biomarkers Using Plethesmography Directed Fluid Management in Major Abdominal Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202002537852294

Enrollment

Registered

2020-02-17

Start date

2020-02-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Circulatory System Surgery Kidney Disease Anaesthesia

Interventions

standard fluid therapy

plethesmography based goal directed therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with physical status American Society of Anaesthesiologists (ASA) I and II who will be scheduled for elective major abdominal surgery (is defined as any surgery with intraperitoneal approach performed under general anesthesia and the predictable postoperative hospitalization and length of stay at least two days) with combined general epidural anaesthesia and will be admitted to Alexandria Main University Hospital.

Exclusion criteria

Exclusion criteria: 1- Extremes of age (below 18 years and above 65 years). 2. Chronic kidney disease. 3. Perioperative use of nephrotoxic drugs. 4. Post-renal transplant patient. 10 5. Hepatic patient. 6. Cardiac patients. 7. Increased intra-abdominal pressure and abdominal laparoscopic surgery. 8. Diabetes mellitus. 9. Peripheral arterial occlusive disease. 10. Pregnancy. 11. Any plethesmography reading with a corresponding core temperature not within the range of 36 ± 1 °C at any time during the surgery. 12. Surgical patients at severe nutritional risk by the presence of at least one of (weight loss >10-15% within 6 months, BMI <18.5 kg/m2, preoperative serum albumin <3 g/dl with no evidence of hepatic or renal dysfunction).(21)

Design outcomes

Primary

Measure	Time frame
The primary outcome is to assess the capability of early prediction of acute kidney injury (defined as KDIGO stage = 1) using urinary G1 cell cycle arrest biomarkers in patients undergoing major abdominal surgery managed by plethesmography based goal directed fluid therapy.	—

Secondary

Measure	Time frame
The secondary outcome is to evaluate the postoperative impact of goal directed therapy in patients undergoing major abdominal surgery as regards: ? The return of normal peristalsis. ? Haemodynamic compromise episodes in the post-operative period. ? The need of renal replacement therapy. ? Length of hospital stay.	—

Countries

Egypt

Contacts

Public Contactmaha ghanem

head of the ethics committee Alexandria university faculty of medicine.

alexmedethics@yahoo.com+201287740750

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026