Assessing the effectiveness of community case management of malaria (CCM-malaria) for all ages in Farafangana District, Madagascar

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202001907367187

Enrollment

1680

Registered

2020-01-22

Start date

2020-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Interventions

Control arm

Intervention arm

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria for surveys conducted at baseline (october-december 2019) and endline (october-december 2021) are: - Individuals older than 2 months from one of the 1680 households selected at random - Who spent at least 7 nights in the household during the 2 weeks prior to the survey - With an informed consent signed by the head of the household or representative - In addition, biological samples (Rapid Diagnostic Test for malaria and filter paper) will be obtained from children aged 2 months to 14 years, with an assentment signed for individuals 7 to 14 years old. Inclusion criteria for the intervention (community case management of malaria): - Individuals older than 2 months living in the catchment area of one of the 15 health centers in the intervention arm (Farafangana District, Madagascar) - Without malaria signs of severity (WHO definition)

Exclusion criteria

Exclusion criteria: Exclusion criteria for the intervention (community case management of malaria): - Pregnant women - Aged 2 months or less - With malaria signs of severity (WHO definition)

Design outcomes

Primary

Measure	Time frame
Proportion of individuals two months of age or older, reporting a fever in the previous 2 weeks who were tested for malaria by a CHW or at a health facility by a health worker.	—

Secondary

Measure	Time frame
Proportion of children <5 years, children 5- 14 years, and those aged 15+ years with febrile illness in the previous 2 weeks who: 1) sought care for that illness; 2) were tested for malaria; and 3) were treated with an appropriate antimalarial if tested positive for malaria ;Community-level parasite prevalence in children 2 months to 14 years (<5 and 5 – 14 years) of age as measured by malaria RDT and by serological testing using dried blood spots collected on filter paper.;Proportion of suspected pneumonia and diarrhea in children <5 years who sought care and who received appropriate treatment ;Acceptability of the extension to all ages of CCM-malaria, according to community members, CHWs, and health facility providers. This will be assessed through qualitative surveys. ;Total costs, resource needs (commodities, workload changes), the cost per patient, and the cost-effectiveness of extending community case management to all ages, as compared to the standard iCCM strategy. This will be measured by economic evaluation.	—

Measure

Time frame

Proportion of children <5 years, children 5- 14 years, and those aged 15+ years with febrile illness in the previous 2 weeks who: 1) sought care for that illness; 2) were tested for malaria; and 3) were treated with an appropriate antimalarial if tested positive for malaria ;Community-level parasite prevalence in children 2 months to 14 years (<5 and 5 – 14 years) of age as measured by malaria RDT and by serological testing using dried blood spots collected on filter paper.;Proportion of suspected pneumonia and diarrhea in children <5 years who sought care and who received appropriate treatment ;Acceptability of the extension to all ages of CCM-malaria, according to community members, CHWs, and health facility providers. This will be assessed through qualitative surveys. ;Total costs, resource needs (commodities, workload changes), the cost per patient, and the cost-effectiveness of extending community case management to all ages, as compared to the standard iCCM strategy. This will be measured by economic evaluation.

—

Countries

Madagascar

Contacts

Public ContactNicole Prada

Research and scientific coordinator at Institut Pasteur Madagascar

nicole.prada@pasteur.mg+261326394076

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026