Skip to content

Evaluation of Platelet Rich Fibrin Regenerative Pulpotomy in Mature Permanent Molars with Irreversible Pulpitis

Evaluation of Platelet Rich Fibrin Regenerative Pulpotomy in Mature Permanent Molars with Irreversible Pulpitis (A RANDOMIZED CONTROLLED TRIAL)

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
PACTR
Registry ID
PACTR202001824413147
Enrollment
48
Registered
2020-01-15
Start date
2018-06-01
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health

Interventions

PRF Pulpotomy capped by MTA
PRF Pulpotomy capped with Biodentine

Sponsors

Department of Conservative Dentistry Faculty of Dentistry Alexandria University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Male or female Patients with age ranging from 18 to 50 years old. 2) Patients complaining from intermittent or spontaneous, sharp or dull, localized, diffuse, or referred pain. 3) Patients’ selected teeth presented with fully developed roots. 4) Selected teeth should give positive responses to cold testing. 5) Selected teeth eliciting prolonged episodes of pain on rapid exposure to dramatic temperature changes and lasting even after the thermal stimulus had been removed. 6) Periapical radiographs showed deep carious lesions. 7) Soft tissues around the tooth were normal. 8) The patients were free from any coagulation disorders, with normal platelets count.

Exclusion criteria

Exclusion criteria: 1) Badly broken or non-restorable teeth. 2) Patients with multiple teeth seeking root canal treatment in the same side. 3) Teeth with Pathological mobility. 4) Pus discharge through an associated sinus tract. 5) Radiographic internal or external resorption or furcation radiolucency. 6) Medically compromised patients.

Design outcomes

Primary

MeasureTime frame
The aim of the present study is to assess the clinical and radiographic success rate of the regenerative pulpotomy procedure done in irreversibly inflamed permanent mature teeth using: a) Biodentine. b) Mineral trioxide aggregate (MTA). c) Platelet rich fibrin (PRF) and Biodentine. d) Platelet rich fibrin and Mineral trioxide aggregate.

Secondary

MeasureTime frame
CBCT analysis is done immediate post-operative and at the end of the follow up period ;is to evaluate the ability of PRF membrane to regenerate the coronal pulp and maintaining the tooth vitality using pulse oximetry.

Countries

Egypt

Contacts

Public ContactSybel;Ashraf Moussa;Zaazou

Professor of Endodontics Faculty of Dentistry Alexandria University;Professor of Endodontics Faculty of Dentistry Alexandria university

sybel_moussa@yahoo.com;ashrafzaazou@hotmail.com+201223409497;+201223326647

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026