Genetic Diseases Haematological Disorders Pregnancy and Childbirth Intrauterine growth restriction, preeclampsia
Conditions
Interventions
Aspirin
Placebo
Sponsors
TETFUND
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Age 18 years and above Singleton fetus Women with sickle cell anaemia i.e. Haemoglobin SS. 16 weeks gestation or less at recruitment, confirmed by an ultrasound scan or certain last menstrual period dates
Exclusion criteria
Exclusion criteria: Other sickle cell disease variants eg Hb SC Women with associated medical conditions in pregnancy eg HIV infection, diabetes mellitus, chronic hypertension, renal disease, sickle nephropathy Women with multiple pregnancy Hypersensitivity to aspirin History of vaso-occlusive crisis in the last 4 weeks History of blood transfusion in the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intrauterine growth restriction, birth weight below the 10th centile for gestational age on INTERGROWTH 21 birthweight charts, or stillbirth, or fetal death or miscarriage | — |
Secondary
| Measure | Time frame |
|---|---|
| preeclampsia;maternal death, preterm delivery, number of crises, need for blood transfusion;Complications such as - Urinary tract infection - Lower Respiratory tract infection - Acute chest syndrome - Retained placenta - Placental abruption ;Potential adverse effects such as - Vaginal bleeding - Epigastric pain - Heartburn | — |
Countries
Nigeria
Contacts
Public ContactOchuwa Babah
Lecturer and Consultant Obstetrician and Gynaecologist Ultrasound and Fetal Medicine Unit College of Medicine of University of Lagos and Lagos University teaching Hospital Idi Araba Lagos
Outcome results
None listed