Anaesthesia
Conditions
Interventions
Group I Pregabalin Oral Capsule
Group II Placebo orla capsule
Sponsors
sherif kamal arafa
Amir abuozikary el sayed
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients included in our research were that enrolled for DCR operation with limited age between 25-60 years old and had American Society of Anesthesiologist physical status of I and II.
Exclusion criteria
Exclusion criteria: While those with pregabalin hypersensitivity or its analogue, ASA III or IV or V, hepatic, renal insufficiency, respiratory disorders or chest problems, hypertensive patients, cardiac disorders, history of taking antihypertensive or ß blockers or any cardiac medication, coagulation disorders, previous seizure, history of taking pregabalin previously, drug abuse, cognitive disorders and patients refused to share in study protocol; all were excluded from our research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain was assessed using 0-10 visual analogue score (VAS) where 0 represents no pain and 10 worst pain imaginable. Pain scores were recorded at 1, 2, 4, 8, 12, and 24h postoperative. | — |
Secondary
| Measure | Time frame |
|---|---|
| - The total dose of nitroglycerin (mg) used for each patients. - The quality of surgical field was also recorded using Fromm and Boezaart scale [12], where 0 grade represent no bleeding, 1 grade represent slight bleeding & no need for blood suction, 2 grade represent slight bleeding & sometimes blood has to be suctioned, 3 grade represent slight bleeding & blood has to be often suctioned (operative field was clear for few seconds after suction), 4 grade represent average bleeding & blood has to be frequent suctioned (operative field was clearly visible immediately after suction), 5 grade represent massive bleeding& regular blood suction required ( continuous non stopped bleeding that may be faster than suction and required another suction and multiple gauze ; hence surgical field became more obscured and non-visible that made the operation was so hard and may be difficult). - Time to first postoperative rescue analgesic request. - Total analgesic consumption in the first 24 h postoperatively was recorded. - Incidence of complications including postoperative nausea and vomiting (PONV), dizziness, somnolence, visual disturbance, headache, urine retention, hypotension, bradycardia, confusion, and sedation (assessed on a four-point scale where 0 = alert, 1 = quietly awake, 2 = asleep but easily aroused, and 3 = deep sleep) were recorded during first 24 hours postoperatively. | — |
Countries
Egypt
Contacts
Public ContactSherif Arafa
lecturer of anesthesia and ICU
Outcome results
None listed