sepesis and renal impariment Kidney Disease
Conditions
Interventions
received conventional treatment sepsis and placebo tablet
received conventional treatment sepsis and Ivabradine tablet
Sponsors
amr sobhy
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: age 18-60 years old arriving (ASUICU) diagnosed with sever sepsis = 24 h according to Surviving Sepsis Campaign Guidelines Committee (3) with Sinus rhythm with heart rate = 95 bpm( after adequate resuscitation) and early renal impairment de?ned by the RIFLE classi?cation (9) (when increased plasma creatinine ×1.5 or GFR decrease >25% of normal range for age or urine output <0.5 ml/kg/h×6 h).
Exclusion criteria
Exclusion criteria: patients with pre-existing renal or started renal dialysis, hypersensitivity to the drug, pregnancy, severe hepatic or cardiac insufficiency , Sick sinus syndrome, Sinu-atrial block pacemaker-dependency ,3rd degree AV block, Use antifungals of the azole -type (ketoconazole, itraconazole), macrolide antibiotics (clarithromycin).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| is to determine whether ivabardine could reduce heart rates to be less than the predefined threshold of 95/min with improvement of kidney function by 25% within 72 hours from the start of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| is to assess prevention of dialysis, vasopressor dosage consumption, ICU hospital stay and mortality. | — |
Countries
Egypt
Contacts
Public ContactAKTHAM ADEL
AIN shams university faculty of medicine department of anesthesia I.C.U and pain management
Outcome results
None listed