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Comparative Study of Patients Outcomes by Using Dexmedetomidine with Bupivacaine versus Bupivacaine Alone in Ultrasound-Guided Thoracolumbar Interfacial Plane Block for Spine Surgeries

Comparative Study of Patients Outcomes by Using Dexmedetomidine with Bupivacaine versus Bupivacaine Alone in Ultrasound-Guided Thoracolumbar Interfacial Plane Block for Spine Surgeries

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
PACTR
Registry ID
PACTR201911745756018
Enrollment
52
Registered
2019-11-14
Start date
2019-10-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Ultrasound guided Thoracolumber interfascial plane block
Ultrasound guided thoraclumber intefascial plane block

Sponsors

Mohamed zakarea wfa
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: ASA physical status I/II Elective spine surgeries (laminectomy and spinal fixation) at the level of thoracic and lumber vertebra.

Exclusion criteria

Exclusion criteria: patient refusal. Surgeries involving more than four intervertebral spaces. Bleeding disorders (coagulopathy). Mental dysfunction. History of allergy to local anesthetics. Pregnant or lactating patients

Design outcomes

Primary

MeasureTime frame
Numerical Rating Scale (NRS) for pain that ranged from (0 = no pain) to (10 = intolerable pain). If score is >3 will need analgesia in the form of morphine 0.05 mg/kg will be given till NRS decreases to =3. NRS will be assessed and recorded on arrival to the Recovery Unit, 4,8,12,18,24 h after the operation,

Secondary

MeasureTime frame
Consumption of anesthetic drugs. Stress response by measuring serum cortisol level which will be measured preoperatively, at time of skin incision, 30 min after skin incision, after skin closure, 6h and 24 h postoperatively. Hemodynamic (mean arterial blood pressure and heart rate) will be recorded 5 min after induction of general anesthesia, 5 min after thoracolumbar interfascial plane block, every 30 min till the end of the surgery, at discharge to PACU, 2 h ,4 h, 8 h, 10h, 12 h., 18 h and 24 h postoperatively. Time of extubation after stopping all anesthetic drugs. Time of the first dose of rescue analgesia (morphine). Number of patients received rescue analgesia. Total doses consumption of rescue analgesia

Countries

Egypt

Contacts

Public ContactGhada Elbradey

Professor

ghada.elbaradi@med.tanta.edu.eg01091206301

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026