Hookworm infection
Conditions
Interventions
mebendazole drug
Sponsors
University of Gondar
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Written informed consent signed by parents and/or legal guardians; and a verbal assent (children <18 years) according to Ethiopian regulation. • Able and willing to be examined by a study physician at the beginning of the study. • Able and willing to provide required stool samples at the beginning (baseline) and two to three weeks after treatment (follow-up). • Positive for hookworm eggs in the stool. • No recent anthelminthic treatment (within past 4 weeks). • Negative pregnancy test (girls =12 years) • Apparently health individual; based on medical history, physical examination, vital signs, hemoglobin level were included • Children who were able to chew the drug were subjected for randomization • Participant had hemoglobin level above 8g/dl
Exclusion criteria
Exclusion criteria: • Individual who has taken any form of medication containing mebendazole or any other treatment for STH infection within 30 days of entry into the study • Who had diarrhea at the time of the first sampling, • Who experience a severe concurrent medical condition, • Participant with haemoglobin level below 8g/dl, • Child with known history of allergic reaction to mebendazole, and • Participants infected with other parasitic infection were excluded from the allocated treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure rate or CR. CR means the proportion of individual hosts positive for parasites who become parasitologically negative after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Arithmetic mean of Feacal Egg Reduction Rate OR ERR. ERR is the arithmetic mean egg count at baseline of the treatment group minus mean egg count at the end of treatment period divided by the mean egg count at the baseline and express it in percent. | — |
Countries
Ethiopia
Contacts
Public ContactMulugeta Aemero
Department head of tropical and infectious diseases University of Gondar
Outcome results
None listed