Anti-inflammatory effect of ketamine versus dexmedetomidine in laparoscopic hysterectomy

Effects of intraoperative ketamine versus dexmedetomidine on release of inflammatory mediators in laparoscopic hysterectomy. Prospective randomized trial.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR201910617459894

Enrollment

Registered

2019-10-25

Start date

2019-11-10

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urological and Genital Diseases Anaesthesia

Interventions

ketamine

general anesthesia only

dexmedetomidine

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: seventy five female patients, aged 30-60, ASA physical status I –II, scheduled for elective laparoscopic hysterectomy

Exclusion criteria

Exclusion criteria: patient refusal, severe respiratory or cardiac disorders, hepatic or renal insufficiency, allergy to any of the study drugs, severe obesity (body mass index >35 kg m-2), uncontrolled diabetes, use of any drug that might affect the immunity as chemotherapy or hormonal treatment.

Design outcomes

Primary

Measure	Time frame
assessment of the inflammatory mediators; tumor necrosis factor-alpha (TNF-a), interleukin 6 (IL-6), and C-reactive protein (CRP)	—

Secondary

Measure	Time frame
Mean arterial blood pressure and heart rate ;Recovery time ;Adverse effects: postoperative nausea and vomiting, over-sedation,bradycardia, hypotension, psychomimetic change as agitation, hallucinations, or vivid dreams	—

Countries

Egypt

Contacts

Public ContactLamees Dawood

Assistant professor

Bosbos193@yahoo.com+201225100563

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 7, 2026