HIV/AIDS
Conditions
Interventions
tenofovir disoproxil fumarate plus lamivudine plus efavirenz
African potato hypoxis tablets
Sponsors
University of Zimbabwe
State University of New York at Buffalo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The following patients were eligible: HIV infected On treatment with Tenofovir Disoproxil Fumarate/ lamivudine/ efavirenz regimen Started this regimen for at least 6 months Adult males or females between 18-60 years Weighing at least 50 kg Females have a negative pregnancy Females are non-lactating Females practice birth control methods willing and able to consume African potato
Exclusion criteria
Exclusion criteria: The following patients were ineligible: History of illicit drug use Consumes grapefruit juice/ alcohol/ tobacco for at least 48 hours before enrolment and throughout the study period. Has any acute illness Family history of cardiac complications. Taking any medications other than the study medications without the prior approval of the study team
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC - Area under the plasma concentration-time curve. Baseline, day 1 and post African potato use, day 11. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cmax - maximum concentration following dose administration;Tmax - time to maximum concentration following dose administration;elimination half-life ;Kel - elimination rate constant | — |
Countries
Zimbabwe
Contacts
Public ContactCelia M.J Matyanga
PhD Candidate
Outcome results
None listed