Efficacy of midazolam and dexmedetomidine for attenuating the hormonal stress response to endotracheal intubation in hypertensive adult patients undergoing elective surgery.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR201909641727181

Enrollment

Registered

2019-09-20

Start date

2018-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

midazolam group

dexmedetomidine group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ASA physical status II & III, aged 18–65 years, scheduled for elective surgery, and known to be hypertensive with good control ( blood pressure lower than 140/90), were included in the study.

Exclusion criteria

Exclusion criteria: Patients were excluded if they have known allergy to any of the study drugs, arterial blood pressure more than 140/90, preoperative arrhythmias, tachycardia (heart rate > 100 beats per minute), bradycardia (heart rate 30), and suspected difficult intubation.

Design outcomes

Primary

Measure	Time frame
the hemodynamics which includes mean arterial blood pressure (MABP) and heart rate (HR)	—

Secondary

Measure	Time frame
biochemical end point through serum cortisol and serum norepinephrine level measurement (reflecting the magnitude of the hormonal stress responses	—

Countries

Egypt

Contacts

Public Contacthesham maged

heshammaged@yahoo.com000123548537

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026