Evaluation of two different fluids regimens on central venous-to-arterial carbon dioxide difference (pco2 gap)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201909633074119

Enrollment

Registered

2019-09-16

Start date

2019-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

crystalloid therapy

colloid therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled for elective major orthopedic surgeries will be selected with the following inclusion criteria: ASA grade I-III, Age between 40-70 years old, who were to undergo major elective orthopedic surgery expected to last at least 4 hours.

Exclusion criteria

Exclusion criteria: Exclusion criteria of the patients: overweight (BMI>35), left ventricular ejection fraction below 45%, significant cardiac arrhythmias, valvular lesions, coagulation disorders, perioperative renal insufficiency, impaired hepatic function, allergy to any drug used in this study, preoperative infection and pregnancy.

Design outcomes

Primary

Measure	Time frame
central venous-to-arterial carbon dioxide difference (Pcv-aCO2)	—

Secondary

Measure	Time frame
Central venous oxygen saturation (Scv O2) , lactate level and Hemodynamic variables: heart rate (beats/minute), mean arterial blood pressure (mmHg), central venous pressure (mmHg), oxygen saturation and urine output.	—

Countries

Egypt

Contacts

Public ContactAmal Mohamed

Secretary of Research and opinion in Anesthesia and intensive care Journal

amalasaic@gmail.com+201281560053

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026