Surgery
Conditions
Interventions
Propofol in cardioplegia
Placebo in 50 patients will be as a controlled group.
Propofol in the aortic line before and after aortic cross clamp
Sponsors
Tanta University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study will include all patients subjected to valve replacement or repair due to rheumatic affection. Those patients will be categorized into three groups: *Group 1(patients with propofol in the cardioplegia and placebo injection in the aortic line). *Group 2(patients with propofol injection in the aortic line before and after the aortic cross clamp and placebo injection in the cardioplegia). *Group 3(patients with placebo injection either in the cardioplegia and aortic line).
Exclusion criteria
Exclusion criteria: Patients less than 18 years old and more than 70 years old. Patients with coronary artery disease. Patients subjected to complex aortic surgery(arch or root surgery). Patients with allergy to propofol. Emergency cardiac surgery. Redo cardiac surgery. Minimal invasive cardiac surgery. Non-rheumatic valve pathology. Patients with end stage renal failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac troponin T level | — |
Secondary
| Measure | Time frame |
|---|---|
| Echocardiography,liver function test,renal function test,cross clamp time,total bypass time, reperfusion time, recovery time,need for defibrilator, ICU stay and morbidty. | — |
Countries
Egypt
Contacts
Public ContactEhab;Abd Elhady Wahby;Taha
Professor of Cardiothoracic surgery at Tanta University Hospital;Professor of Cardiothoracic surgery at Tanta University Hospital
Outcome results
None listed