Skin and Connective Tissue Diseases
Conditions
Interventions
Group 1
Group 2
Sponsors
Sohag University Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Healthy female aged between 18 to 50 years old fitzpatric skin type III and V.
Exclusion criteria
Exclusion criteria: Personal or family history of skin cancer, especially melanoma. Consumption of any preparations containing glutathione within 1month of enrollment. Pigmentary disorders or any dermatoses, which may affect the measurement within the study areas. Known hypersensitivity to glutathione. Current pregnancy and lactation. Current use of oral contraceptive pills or current receipt of hormone replacement therapy. Regular participation in vigorous activities (e.g. sports) that includes exercise; occupational or leisure activities that involve daily sun exposure between 10.00 hours and 15.00 hours A history of autoimmune disease, or immunodeficiency. Major surgery, active or recent systemic infection within the previous four weeks. History of liver diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-resolution photographs will be taken using smart phone, before treatment, at the end of treatment, 3 months after end of treatment to : Sun exposed areas: Face (left and right sides)- extensor surface of forearm. Sun protected areas: mid-sternum, upper & inner arms (left and right). Using a physician visual analog scoring system, 2 independent dermatologists will rate the patient’s overall aesthetic improvement from 0-10 based on a comparison between the baseline, end of therapy and 3 months follow up visit photographs (Barikbin et al., 2017). ;Laboratory investigations: Complete blood picture- liver functions- serum creatinine- Thyroid stimulating hormone (TSH).;Safety evaluation: Any adverse effects noticed by participants and or physician will reported during the treatment and the follow up period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients satisfaction Participant will be asked to grade the over all response using a 4 point rating scale: as follows, 4-very satisfactory; 3-moderately satisfactory; 2-minimally satisfactory; 1-not satisfactory (Arjinpathana and Asawanonda, 2012). ;The Dermatology Life Quality Index (DLQI): The DLQI consists of 10 questions concerning symptoms and feelings, daily activities, leisure, work, and school, personal relationships and treatment. Each question is answered by a tick box: ‘‘not at all’’, ‘‘a little’’, ‘‘a lot’’ or ‘‘very much’’. Each question is scored from0 to 3 and the scores summed, giving a range from 0 (no impairment of life quality) to 30 (maximum impairment). All questions relate ‘‘to the last week’’. The DLQI was designed to be used in adults over the age of 18 years (Finlay and Khan, 1994). | — |
Countries
Egypt
Contacts
Public ContactAlaa ;Essam A Mostafa;Nada
Resident at Department of Dermatology Albaliana Hospital Sohag;Professor of Dermatology Faculty of Medicine Sohag University
Outcome results
None listed