Schistosomiasis
Conditions
Interventions
Praziquantel
Sponsors
Bernhard Nocht Institute of Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Informed consent signed (from the parents for minors) - Expected residency in the area of the study site for the next 24 months - Pregnant women between their 5th and 6th months of pregnancy - Children born from an enrolled mother, including twins - Willingness to comply with the protocol requirements including: sampling and treatment for both mothers and children
Exclusion criteria
Exclusion criteria: - Fever (temporary exclusion) - History of transfusion - History of congenital anaemia - Epileptic or convulsive episodes - Non-pregnant women - Pregnant women younger than 16 years old - Pregnant women who have not completed their 4th month of pregnancy - Pregnant women over their 6th month of pregnancy - Pregnant women who do not live in the area of the CSB - Children born from mothers not enrolled in the study - Children born in a CSB different from the ones in which the mothers were enrolled
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height for age at 24 months will be used to measure the impact of TBST. Weight and height of children will be measured at birth, at 9 months and 24 months of age.;Maternal Hb at 24 months after delivery will be used to measure the impact of TBST. Maternal Hb will be measured at enrolment before delivery (8th month of pregnancy), 9 months after delivery and at two years after delivery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity and specificity of the POC-CCA test compared to the panel reference standard (measured in the cross-sectional study at Imerentsiatosika and Andina).;Prevalence of S. mansoni and S. haematobium in pregnant women and U5 children;Women’s quality of life related to health (measured by EQ-5D tool) and capacity to work and earn in routine activities;Costs of the interventions | — |
Countries
Madagascar
Contacts
Public ContactDaniela Fusco
Group leader BNITM
Outcome results
None listed