Nervous System Diseases
Conditions
Interventions
Alteplase group
Aspirin
Sponsors
Faculty of medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1- Age 18 year or older 2- Clinical diagnosis of ischemic stroke with measurable neurological deficit.
Exclusion criteria
Exclusion criteria: 1. Evidence of intra-cranial hemorrhage on non-contrast CT (computerized tomography). 2. Clinical suspicion of sub-arachnoid hemorrhage even with normal CT. 3. CT shows multi-lobar infarction (hypo-density greater than 1/3 cerebral hemisphere). 4. History of intra-cranial hemorrhage. 5. Uncontrolled hypertension: at time treatment systolic blood pressure remains>185 mm hg or diastolic blood pressure remains>110 despite repeated measurements. 6. Known arteriovenous malformation, neoplasm, or aneurysm. 7. Witnessed seizure at stroke onset. 8. Acute bleeding tendencies as low platelet count 22 (sever deficit) or <4 and no dysphasia (mild deficit) or rapidly improving symptoms. 13. 14 days post-operative or post trauma. 14. Recent GI or urinary tract hemorrhage (prior 21 days). 15. Recent acute myocardial infarction (prior 3 months). 16. Post myocardial infarction pericarditis. 17. Glucose level < 50 which is resistant for correction by glucose infusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| is assessed changes in neurological deficits 24 hours after the onset of stroke as a measure of the activity of t-PA by National Institution of Health Stroke Scale NIHSS interpretation. Early neurological improvement was defined as an NIHSS score of 0 or 1 at 24 h after treatment or a decrease of 4 points or more in NIHSS score at 24 h after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale MRS with MRS 0 to 1 as favorable outcome and MRS more than 2 as non favorable outcome. | — |
Countries
Egypt
Contacts
Public ContactNadia;Amr Mohee El Din Bahgat Abbas;El fatatrey
Lecturer of Anesthesiology and Intensive Care;Assistant Professor of Neuropsychiatry Faculty of Medicine Alexandria University
Outcome results
None listed