NICOTINE ADDICTION
Conditions
Interventions
Group 1 Nicotine replacement therapy
Group 2 Bupropion
Group 3 NRT and Bupropion
Group 4 Placebo
Sponsors
Dalia Abdellateif Abdelghany
pharmaceutics Department. Faculty of Pharmacy
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1- Apparently healthy cigarette smokers 2- Smokers who were motivated to quit and were willing to attend scheduled study visits. 3- Smokers aged 18 years or over. 4- Consent had been obtained. 5- Smokers with no contraindication to treatment with bupropion or nicotine gum.
Exclusion criteria
Exclusion criteria: 1- Smokers who were not sufficiently motivated to quit. 2- Smokers under the age of 18 years. 3- Pregnant or nursing mothers. 4- Hypersensitivity to bupropion or nicotine gum. 5- Smokers with diabetes or hypertension. 6- History of cardiac or chest diseases. 7- History of hepatic or renal impairment. 8- History of epilepsy or head trauma. 9- Risk factor for seizures. 10- Evidence of CNS tumors 11- Smokers with a current/previous diagnosis of bulimia/anorexia nervosa. 12- Drug or alcohol abusers. 13- History of bi-polar mode or psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess smoking status either (success to stop smoking, failure to stop smoking, lapse or relapse) at third months from starting treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess smoking status either (success to stop smoking, failure to stop smoking, lapse or relapse) at six months from starting treatment. | — |
Countries
Egypt
Contacts
Public ContactNesrine Farrag
lecturer of public health. Manosura University
Outcome results
None listed