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Effects of Walking Exercise on Brain-Derived Neurotrophic Factor, Cognition, Participation and Quality of Life among Stroke Survivors

Walking Exercise Versus Cognitive Rehabilitation Protocols on Brain-Derived Neurotrophic Factor, Cognition, Participation and Quality of Life among Stroke Survivors

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
PACTR
Registry ID
PACTR201903762696119
Enrollment
57
Registered
2019-03-18
Start date
2019-03-18
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases

Interventions

Combined Rehabilitation Protocol
Aerobic exercise
Cognitive rehabilitation

Sponsors

Bayero Uiversity Kano
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. First incidence of ischaemic or haemorrhagic stroke with blood pressure under control 2. cognitive function score of 10 to 25 on the Montreal Cognitive Assessment (MoCA) 3. Adequate balance control of less than 30 seconds scores indicated by Timed Up-and-Go (TUG) test 4. Able to read and write in either English or Hausa language 5. Mild to moderate upper limb impairment with wrist, metacarpophalangeal and interphalangeal joint extension of more than 20 degrees and preserved ability to grasp 7. Able to complete self-paced 6 Minutes Walk (6MW) test at an intensity of perceived exertion of 12 to 13 on the Borg 6-20 Scale.

Exclusion criteria

Exclusion criteria: a) Individuals with severe cardiac problems as determined using physical activity readiness questionnaire and aerobic exercise testing. This group of participants may not be able to cope with the exercise intensity. b) Individuals with severe depression as indicated by Physical Health Questionnaire (PHQ) score of more than 15 and stroke survivors with other conditions that may cause cognitive impairments such as Parkinson’s disease, Alzheimer’s disease or traumatic head injury etc. c) Individuals with severe joint disorders such as osteoarthritis, rheumatoid arthritis that may become worse during exercise or can make performance of exercise difficult.

Design outcomes

Primary

MeasureTime frame
Cognition ;Brain-derived neurotrophic factor

Secondary

MeasureTime frame
Quality of life;Participation

Countries

Nigeria

Contacts

Public ContactOlubukola A. Olaleye

University of Ibadan Nigeria

olubukolaolaleye@yahoo.com+2348100965871

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026