Bukhali: Building knowledge, optimising physical and mental health, and setting up healthier life trajectories in South African women

Conditions

Nutritional, Metabolic, Endocrine Pregnancy and Childbirth Paediatrics Obesity

Retnakaran R, Shen J, Hung RJ, Lye SJ, Norris SA.

2026-09-03

10.1136/bmjdrc-2026-006131

Cost-effectiveness of a complex continuum of care intervention targeting women and children: protocol for an economic evaluation of the Bukhali trial in South Africa

Tom Palmer, Rolando Leiva Granados, Catherine E. Draper, Shane A. Norris, Neha Batura

BMJ Open2024-05-01

10.1136/bmjopen-2023-080166

A qualitative analysis of community health worker perspectives on the implementation of the preconception and pregnancy phases of the Bukhali randomised controlled trial

Larske M. Soepnel, Shane A. Norris, Khuthala Mabetha, Molebogeng Motlhatlhedi, Nokuthula Gloria Nkosi et al. (7 authors)

PLOS Global Public Health2024-03-146 citations

10.1371/journal.pgph.0002578

The role of a community health worker-delivered preconception and pregnancy intervention in achieving a more positive pregnancy experience: the Bukhali trial in Soweto, South Africa

Larske M. Soepnel, Khuthala Mabetha, Shane A. Norris, Molebogeng Motlhatlhedi, Nokuthula Gloria Nkosi et al. (8 authors)

BMC Women s Health2024-03-053 citations

10.1186/s12905-024-02982-8

Developing Policy for the Healthy Life Trajectories Initiative: Going from National to International

Dimitri Patrinos, Erika Kleiderman, William D. Fraser, Ma’n H. Zawati, Shane A. Norris et al. (11 authors)

Biopreservation and Biobanking2023-05-162 citations

10.1089/bio.2022.0198

A protocol for monitoring fidelity of a preconception-life course intervention in a middle-income setting: the Healthy Life Trajectories Initiative (HeLTI), South Africa.

Soepnel LM, Draper CE, Mabetha K, Dennis CL, Prioreschi A, Lye S, Norris SA.

2022-09-066 citations

10.1186/s13063-022-06696-w

Evaluation of a Text Messaging Intervention to Promote Preconception Micronutrient Supplement Use: Feasibility Study Nested in the Healthy Life Trajectories Initiative Study in South Africa

Larske M. Soepnel, Michelle C. McKinley, Sonja Klingberg, Catherine E. Draper, Alessandra Prioreschi et al. (7 authors)

JMIR Formative Research2022-08-189 citations

10.2196/37309

Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (<i>Bukhali</i>): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI)

Shane A. Norris, Catherine E. Draper, Alessandra Prioreschi, Cornelius M. Smuts, Lisa J. Ware et al. (36 authors)

BMJ Open2022-04-0151 citations

10.1136/bmjopen-2021-059914

Interventions

Bukhali

Bukhali Call Centre

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: (i) women age 18-28 years at baseline measurement

Exclusion criteria

Exclusion criteria: (i) women with type-I diabetes, cancer or epilepsy (ii) intellectual disability (iii) who are not able or willing to provide consent

Design outcomes

Primary

Measure	Time frame
Child - Dual-energy X-ray absorptiometry-derived fat mass index (fat mass/height2) of the index-child at age 5 years	—

Secondary

Measure	Time frame
Child - Anthropometry (age- and sex-standardized continuous BMI-z score, BMI growth trajectories, continuous waist circumference z- score, upper arm circumference, head circumference);Child - Cardiometabolic Outcomes: (systolic and diastolic blood pressure, lipid profile, glucose, insulin, insulin resistance);Child - Health Behaviour Outcomes: dietary intake, physical activity, screen time, sedentary behaviour, sleep time;Child - Developmental and Mental Health Outcomes: cognitive, motor skills, communication, behavioural;Mother - Anthropometric Outcomes: overweight and obesity (OWO), DXA-derived body composition, waist circumference;Mother - Health Behaviour Outcomes: dietary patterns, physical activity, screen time, sedentary behaviour, sleep time, tobacco and alcohol use;Mother - Mental Health Outcomes: depressive symptoms, anxiety;Nutrition - aneamia;Physical health - hypertension	—

Measure

Time frame

Child - Anthropometry (age- and sex-standardized continuous BMI-z score, BMI growth trajectories, continuous waist circumference z- score, upper arm circumference, head circumference);Child - Cardiometabolic Outcomes: (systolic and diastolic blood pressure, lipid profile, glucose, insulin, insulin resistance);Child - Health Behaviour Outcomes: dietary intake, physical activity, screen time, sedentary behaviour, sleep time;Child - Developmental and Mental Health Outcomes: cognitive, motor skills, communication, behavioural;Mother - Anthropometric Outcomes: overweight and obesity (OWO), DXA-derived body composition, waist circumference;Mother - Health Behaviour Outcomes: dietary patterns, physical activity, screen time, sedentary behaviour, sleep time, tobacco and alcohol use;Mother - Mental Health Outcomes: depressive symptoms, anxiety;Nutrition - aneamia;Physical health - hypertension

—

Countries

South Africa

Contacts

Public ContactLisa Micklesfield

Associate Professor and Deputy Director

lisa.micklesfield@wits.ac.za+27119331122

Outcome results

None listed