HIV/AIDS Tuberculosis Cryptococcal disease
Conditions
Interventions
Enhanced package of care for TB and Cryptoccocal disease in individuals with advanced HIV
South African standard of care for individuals with advanced HIV disease
Sponsors
Medecins Sans Frontieres OCB
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients aged 18 years and older 2) New HIV positive patients with CD41000 copies/ml and CD4<200 cell counts/ µl 4) Patients returning after defaulting for more than 3 months with a CD4<200 5) Written, informed consent for data collection (control and intervention arms) 6) Written, informed consent for participation in intervention (intervention arm)
Exclusion criteria
Exclusion criteria: 1) Patients requiring hospitalization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients initiated < 200 CD4 retained in care at 6 months and 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients initiated < 200 CD4 diagnosed with extrapulmonary TB and pulmonary TB;Proportion of patients with CD4 <200 found to have cryptococcal antigenaemia;Median time to ART initiation (for naïve);Virological suppression (VL<1000) 6 and 12 months following ART initiation (for naïve) ;TB outcomes for all those diagnosed with TB;Proportion of eligible patients initiating ART on the same day;Disease free survival at 6 months on Fluconazole for the prevention of cryptococcal disease;Overall mortality | — |
Countries
South Africa
Contacts
Public ContactJelena Pavlovic
Epidemiologist
Outcome results
None listed