The Potential Role of Hydrocortisone in Acute Phosphide Poisoning: A Randamized Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR201811766698931

Enrollment

Registered

2018-11-23

Start date

2016-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injury, Occupational Diseases, Poisoning

Interventions

Hydrocortisone

Normal saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients with severe acute phosphide poisoning manifested by systolic blood pressure (SBP) =80 mmHg pH =7.2, or HCO3 =15 meq/L

Exclusion criteria

Exclusion criteria: • Asymptomatic patients. • Patients ingested or exposed to other substances in addition to phosphide. • Patients with major medical conditions (e.g. cardiovascular disease, renal or hepatic failure). • Patients on steroids therapy. • Patients with medical interference by corticosteroid 24 hours before admission.

Design outcomes

Primary

Measure	Time frame
Mortality.	—

Secondary

Measure	Time frame
• Need for mechanical ventilation. • Amount of vasopressors needed for normalization of blood pressure. • Arterial blood pressure at time of discharge. • Duration of hospital stay.	—

Countries

Egypt

Contacts

Public ContactGhada Sagah

Assistant Lecturer of Forensic Medicine and Clinical Toxicology

gh_attia@hotmail.com00201003642188

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026