Circulatory System Pregnancy and Childbirth Preeclampsia and Eclampsia
Conditions
Interventions
Modified Pritchard regimen
Sponsors
University of Michigan
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Antepartum, intrapartum, or postpartum eclampsia with a blood pressure of 140/90 mm Hg or higher after 20 weeks of pregnancy; proteinuria with a dipstick value of +1 or higher; and seizures not attributed to other causes among women with preeclampsia. 2. Severe preeclampsia with diastolic BP=110 mmHg on two occasions or systolic BP =160 mmHg plus at least 2 or more symptoms of imminent eclampsia 3. Patients who have documentation of having received loading dose of MgSO4 at referral clinics prior to referral will be eligible for randomization if they otherwise
Exclusion criteria
Exclusion criteria: 1. Eclampsia with complications (e.g. acute renal failure, HELLP syndrome [hemolysis, elevated liver enzymes, and low platelet count], or pulmonary edema) or 2. Patients with underlying renal disease 3. Contraindication to MgSO4 (e.g. drug hypersensitivity, myasthenia gravis, anuria, or oliguria), 4. Prior intake of any other anticonvulsant, and a history of epilepsy. 5. Refusal to give consent or unable to give consent (eg unconscious)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the occurrence of a fit any time after the completion of the third maintenance dose (MD3) after delivery or last fit, in the study arm or the 6th maintenance dose (MD6) after delivery or last fit in the control arm till 6th week postpartum). | — |
Secondary
| Measure | Time frame |
|---|---|
| The time interval (in hours) from initiation of treatment to the development of diuresis. (Diuresis will be defined as urine output > 400ml/4 hrs);Clinical evidence of toxicity (Absent tendon reflexes, RR <16cpm, coma);Development acute renal failure (urine output <25 mls/hr) after initiation of treatment;Clinically documented pulmonary oedema;Maternal death;Cerebrovascular accident (stroke);Perinatal death;2. 5th minute Apgar score;Respiratory distress (necessitating admission to NICU) | — |
Countries
Ghana
Contacts
Public ContactTITUS BEYUO
Korle Bu Teaching Hospital
Outcome results
None listed