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Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?

Could intraoperative magnesium sulphate protect against postoperative cognitive impairment?

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR201810909649406
Enrollment
80
Registered
2018-10-15
Start date
2018-10-13
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases Anaesthesia

Interventions

Intraoperative magnesium sulphate
intraoperative saline

Sponsors

Beni suef university
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients who are candidate for elective laparoscopic cholecystectomy 2. Patients should have the ability to read, write and do simple calculations 3. All the participants will be required to offer a written informed con¬sent

Exclusion criteria

Exclusion criteria: 1. Patient subjected to gross hemodynamic or ventilatory fluctuations during the operation 2. Patient who developed postoperative shock or major bleeding 3. Patient with a history of neurodegenerative disease 4. Patients with concomitant medical or metabolic illness known to affect cognition 5. Patients with evidence of concomitant cerebrovascular stroke 6. Patient with a history of major head trauma 7. Patient with a history of epileptic fits in the last two years 8. Patient with a history of serious hearing or visual impairment 9. Patients with MRI brain showing structural lesion 10. Patients with a history of exposure to drug, toxic substances, alcohol, industrial agents, heavy metals, or any substance known to affect cognition.

Design outcomes

Primary

MeasureTime frame
cognitive dysfunction

Secondary

MeasureTime frame
postoperative pain

Countries

Egypt

Contacts

Public ContactTamer Nabil

General surgery assistant professor

Tamernbl@hotmail.com01063100888

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026