Anesthetic technique and oxidative stress during radical mastectomy.

Oxidative stress in patients undergoing modified radical mastectomy under sevoflurane compared to total intravenous anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201810868530360

Enrollment

Registered

2018-10-29

Start date

2016-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer

Interventions

sevoflurane

propofol

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: female patients age older than 18 years. who will be scheduled for modified radical mastectomy at the Mansoura University hospitals

Exclusion criteria

Exclusion criteria: Significant renal diseases. Significant hepatic diseases. Significant cardiovascular diseases Suggestive history or signs of active inflammatory or infectious diseases. Previous or bilateral breast surgery. Breast reconstruction. Previous chemotherapy. Anemia and blood transfusion during the last 2 weeks. Receiving vitamins and /or antioxidants (folic acid, omega, flavonoids, Vit A, B, C, D, E etc) during the last two months

Design outcomes

Primary

Measure	Time frame
the perioperative changes in plasma malondialdehyde (MDA) level	—

Secondary

Measure	Time frame
changes in plasma level of glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD)	—

Countries

Egypt

Contacts

Public ContactSamah El Kenany

Lecturer of anesthesia surgical intensive care and pain management

sk_20022000@yahoo.com00201002262557

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026