The effect of pre-emptive intravenous ondansetron on patients presented to elective C.S under combined spinal-epidural anesthesia

The effect of pre-emptive intravenous ondansetron on patients presented to elective C.S under combined spinal-epidural anesthesia: a Randomized controlled study assessing hemodynamic parameters using cardiometry

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201809811205627

Enrollment

Registered

2018-09-11

Start date

2018-09-08

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System Anaesthesia

Interventions

ondansetron group

saline group

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 60 Patients presented for elective cesarean sections American Society of Anesthesiologists (ASA) patient status classification II ages 21-40 years

Exclusion criteria

Exclusion criteria: 1. Age younger than 21 or older than 40 years 2. Major cardiovascular diseases 3. Preexisting hypertension or gestational hypertension, preeclampsia 4. Body mass index greater than 35 kg/m2. 5. Emesis gravidarum 6. Contraindication to neuraxial anesthesia (patient refusal, unstable hemodynamic, and coagulation abnormalities) 7. Any study drugs allergy. 8. emergent cesarean sections, multiple parities (twins/triplets) 9. > 1,000 ml blood loss,

Design outcomes

Primary

Measure	Time frame
The incidence of hypotension will be collected at pre-defined time points: baseline measurement while supine (T0), in the sitting position (T1), immediately after injection of spinal anesthesia (T2), 5 and 10 min after spinal anesthesia while supine (T3, T4), at skin incision (T5), 3 min after skin incision (T6), at newborn delivery (T7), 3 min after delivery (T8), 10 min after delivery (T9) and at the end of surgery (T10).	—

Measure

Time frame

The incidence of hypotension will be collected at pre-defined time points: baseline measurement while supine (T0), in the sitting position (T1), immediately after injection of spinal anesthesia (T2), 5 and 10 min after spinal anesthesia while supine (T3, T4), at skin incision (T5), 3 min after skin incision (T6), at newborn delivery (T7), 3 min after delivery (T8), 10 min after delivery (T9) and at the end of surgery (T10).

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Secondary

Measure	Time frame
changes in the heart rate will be collected at pre-defined time points: baseline measurement while supine (T0), in the sitting position (T1), immediately after injection of spinal anesthesia (T2), 5 and 10 min after spinal anesthesia while supine (T3, T4), at skin incision (T5), 3 min after skin incision (T6), at newborn delivery (T7), 3 min after delivery (T8), 10 min after delivery (T9) and at the end of surgery (T10). and the effect of the APGAR score.	—

Measure

Time frame

changes in the heart rate will be collected at pre-defined time points: baseline measurement while supine (T0), in the sitting position (T1), immediately after injection of spinal anesthesia (T2), 5 and 10 min after spinal anesthesia while supine (T3, T4), at skin incision (T5), 3 min after skin incision (T6), at newborn delivery (T7), 3 min after delivery (T8), 10 min after delivery (T9) and at the end of surgery (T10). and the effect of the APGAR score.

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Countries

Egypt

Contacts

Public Contactnada Omara

assistant lecturer

Dr.nada.emera@gmail.com+02201008372249

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026