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Comparison of Dihydroartemisinin-Piperaquine versus Sulphadoxine-Pyrimethamine for malaria prevention in pregnancy

COMPARATIVE EFFICACY OF SULPHADOXINE-PYRIMETHAMINE AND DIHYDROARTEMISININ-PIPERAQUINE FOR INTERMITTENT PREVENTIVE TREATMENT OF MALARIA DURING PREGNANCY: A RANDOMIZED CONTROLLED TRIAL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR201808204807776
Enrollment
360
Registered
2018-08-07
Start date
2018-08-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria Pregnancy and Childbirth malaria prevention during pregnancy

Interventions

SulphadoxinePyrmethamine
Dihydroartemisinin Piperaquine DHA

Sponsors

Federal Teaching Hospital Abakaliki
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Pregnant women between 14 weeks and 24 weeks gestation with viable pregnancy. 2. Women who have not received intermittent preventive treatment with sulphadoxine–pyrimethamine during the index pregnancy. 3. Women not allergic to sulphadoxine-pyrimethamine or dihydroartemisinin-piperaquine. 4. Women willing to deliver in the study hospital.

Exclusion criteria

Exclusion criteria: 1. Women in the first trimester of pregnancy. 2. HIV positive pregnant women 3. Women allergic to sulphadoxine-pyrimethamine or dihydroartemisini-piperaquine. 4. Women with high-risk pregnancies e.g. medical diseases in pregnancy (sickle cell disease, diabetes mellitus, hypertensive disorders in pregnancy) and multiple gestations. 5. Women who do not consent to the study.

Design outcomes

Primary

MeasureTime frame
prevalence of placental malaria

Secondary

MeasureTime frame
Incidence of symptomatic malaria, adverse birth outcomes, including spontaneous abortion, stillbirth, low birth weight (<2500 g), and preterm delivery (<37 weeks).

Countries

Nigeria

Contacts

Public ContactChidiebere Anikwe

Obstetrician

drchideanikwechristian@gmail.com+2348064165965

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026