Surgery Fertility-female abdominal hysterectomy surgeries
Conditions
Interventions
clozapine group
control group
Sponsors
suez canal university hospital
departemnt of anesthesia ,faculty of medicine ,suez canal university
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1-Adults more than 21 years and less than 60 years of age undergoing abdominal hystrectomy 2-Patients are ASA I (American Society of Anesthesiologists physical status Grade I) = (normal healthy patients), ASA II (American Society of Anesthesiologists physical status Grade II) = (patients with mild systemic disease and no functional limitations) 3-Abdominal hysterectomy under general anesthesia 4-Patients of Body Mass Index (BMI) ¿ 20 and ¿ 30
Exclusion criteria
Exclusion criteria: 1-Refusal of participation in the study 2-A known history of sensitivity to clozapine 3-Schizophrenia or other psychiatric disorder (a previous diagnosis of any psychiatric disorder listed in Diagnostic and Statistical Manual of Mental Disorders IV), history of untreated non-psychotic emotional disorders, cognitive impairment or any difficulties with communication that will impair or interfere with Peri-operative and assessment procedures 4-History of drug dependency or substance addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intraoperative analgesic requirements | — |
Secondary
| Measure | Time frame |
|---|---|
| preoperative sedation using Riker Sedation-Agitation Scale;heart rate;mean arterial blood pressure;duration of surgery from skin incision to skin closure;Total intraoperative mean isoflurane consumption;postoperative recovery using modified Aldrete score;post-perative sedation using Riker Sedation-Agitation Scale;Time of first analgesic request;24 hours morphine consumption by PCA;Adverse effects: dizziness, insomnia, unresponsiveness, agitation, airway obstruction, respiratory depression, or nausea and vomiting;postoperative VAS score at rest;postoperative VAS score at movement | — |
Countries
Egypt
Contacts
Public Contactmohamed abuelnaga
lecturer of anesthesia and intensive care ,faculty of medicine ,suez canal university
Outcome results
None listed