Impact of dexmedetomidine on postoperative biomarkers, length of hospitalisation and mortality in patients undergoing coronary artery bypass graft su

Impact of dexmedetomidine on postoperative biomarkers, length of hospitalisation and mortality in patients undergoing coronary artery bypass graft surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201806003460336

Enrollment

Registered

2018-06-12

Start date

2014-02-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System cardiovascular disease

Interventions

Dexmedetomidine

Saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Left main or triple vessel coronary artery disease. 2. Age above 18 and below 65 years.

Exclusion criteria

Exclusion criteria: 1. Age below 18 or above 65 years. 2. Pregnancy or lactation. 3. Liver dysfunction (AST or ALT > twice the upper range of normal). Normal values (National Health Laboratory Services: AST 5¿40 and ALT 5¿40 units/dl). 4. Sick sinus syndrome. 5. Use of concomitant medication with potential for major drug interactions such as propoxyphene, sodium oxybate and tinazide. 6. Patients requiring preoperative inotropic support. 7. Asthma. 8. Uncontrolled pulmonary congestion as evidenced radiologically and by arterial hypoxemia. 9. Evidence of ongoing infection as indicated by acute phase reaction markers. 10. Patients undergoing combined coronary and valve surgery, or other open heart procedures.

Design outcomes

Primary

Measure	Time frame
hs-cTnT	—

Secondary

Measure	Time frame
2. Length of ICU stay (days). ;3. Length of hospitalisation (days).;4. 30-day postoperative mortality.;5. 1-year mortality.	—

Countries

South Africa

Contacts

Public ContactChris Lundgren

Supervisor

chris.lundgren@wits.ac.za0119339334

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026