combined Nd:YAG laser and PRP injection for treatment of periorbital wrinkles

Clinical and dermoscopic evaluation of combined long-pulsed neodymium:yttrium-aluminium-garnet (1064 nm) laser and intradermal injection of autologous platelet rich plasma in treatment of periorbital wrinkles; a prospective randomized controlled trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201806003306192

Enrollment

105

Registered

2018-04-06

Start date

2018-04-09

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin and Connective Tissue Diseases periorbital wrinkles

Interventions

combined PRP injection and long pulsed Nd:YAG (1064 nm) laser

intradermal injection of PRP

Long pulsed Nd:YAG (1064 nm) laser

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Age: 35-60 years female patients modified Fitzpatrick`s scale II and more all skin phototypes

Exclusion criteria

Exclusion criteria: age60 years male patients modified Fitzpatrick`s scale I smoking blepharocalesis systemic diseases patients who receive oral anticoagulants patients who receive systemic retinoids within 6 months prior to the study patients with history of cosmetic intervention for correction of the periorbital wrinkles any dermatologic disorders other than periorbital wrinkles

Design outcomes

Primary

Measure	Time frame
degree of improvement;patient`s satisfaction	—

Secondary

Measure	Time frame
Persistence of the response, improvement, or worsening	—

Countries

Egypt

Contacts

Public ContactRania Abdelghani

Faculty of Medicine for Girls, Al-Azhar University

rania_abdulghani@hotmail.com+2-01283433887

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026